Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome.

Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome.

The hotspots of structural polymorphisms and structural mutability in the human genome remain to be explained mechanistically. We examine associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination (NAHR) mediated by low-copy repeats (LCRs). Comb...

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Bibliographic Details
Main Authors: Jian Li, R Alan Harris, Sau Wai Cheung, Cristian Coarfa, Mira Jeong, Margaret A Goodell, Lisa D White, Ankita Patel, Sung-Hae Kang, Chad Shaw, A Craig Chinault, Tomasz Gambin, Anna Gambin, James R Lupski, Aleksandar Milosavljevic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3355074?pdf=render

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http://europepmc.org/articles/PMC3355074?pdf=render

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