Helicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulence

Helicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulence

Helicobacter pylori infection is linked to serious gastric-related diseases including gastric cancer. However, current therapies for treating H. pylori infection are challenged by the increased antibiotic resistance of H. pylori. Therefore, it is in an urgent need to identify novel targets for drug...

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Bibliographic Details
Main Authors: Sue-Fen Chiu, Kai-Wen Teng, Po-Chuan Wang, Hsin-Yu Chung, Chun-Jen Wang, Hui-Chun Cheng, Mou-Chieh Kao
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Virulence
Subjects:
helicobacter pylori
d-glycero-d-manno-heptose-1, 7-bisphosphate phosphatase (gmhb)
heptose biosynthesis
lipopolysaccharide
outer membrane vesicle
bacterial pathogenesis
drug target
virulence factor
enzyme kinetics
Online Access:http://dx.doi.org/10.1080/21505594.2021.1938449

Internet

http://dx.doi.org/10.1080/21505594.2021.1938449

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