A new analysis approach of epidermal growth factor receptor pathway activation patterns provides insights into cetuximab resistance mechanisms in head and neck cancer

A new analysis approach of epidermal growth factor receptor pathway activation patterns provides insights into cetuximab resistance mechanisms in head and neck cancer

<p>Abstract</p> <p>The pathways downstream of the epidermal growth factor receptor (EGFR) have often been implicated to play crucial roles in the development and progression of various cancer types. Different authors have proposed models in cell lines in which they study the modes...

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Bibliographic Details
Main Authors: von der Heyde Silvia, Beissbarth Tim
Format: Article
Language:English
Published: BMC 2012-05-01
Series:BMC Medicine
Subjects:
HNSCC
EGFR
cetuximab
drug resistance
matrix factorization
GSEA
pathway signature
Online Access:http://www.biomedcentral.com/1741-7015/10/43

Internet

http://www.biomedcentral.com/1741-7015/10/43

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