Magnetic Combined Cross-Linked Enzyme Aggregates of Ketoreductase and Alcohol Dehydrogenase: An Efficient and Stable Biocatalyst for Asymmetric Synthesis of (R)-3-Quinuclidinol with Regeneration of Coenzymes In Situ

Magnetic Combined Cross-Linked Enzyme Aggregates of Ketoreductase and Alcohol Dehydrogenase: An Efficient and Stable Biocatalyst for Asymmetric Synthesis of (R)-3-Quinuclidinol with Regeneration of Coenzymes In Situ

Enzymes are biocatalysts. In this study, a novel biocatalyst consisting of magnetic combined cross-linked enzyme aggregates (combi-CLEAs) of 3-quinuclidinone reductase (QNR) and glucose dehydrogenase (GDH) for enantioselective synthesis of (R)-3-quinuclidinolwith regeneration of cofactors in situ wa...

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Bibliographic Details
Main Authors: Yuhan Chen, Qihua Jiang, Lili Sun, Qiang Li, Liping Zhou, Qian Chen, Shanshan Li, Mingan Yu, Wei Li
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Catalysts
Subjects:
enzyme immobilization
magnetic nanoparticles
combined cross-linked enzyme aggregates
reuse
(R)-3-quinuclidinol
Online Access:http://www.mdpi.com/2073-4344/8/8/334

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http://www.mdpi.com/2073-4344/8/8/334

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