Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models

Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models

Abstract Background Particular breast cancer subtypes pose a clinical challenge due to limited targeted therapeutic options and/or poor responses to the existing targeted therapies. While cell lines provide useful pre-clinical models, patient-derived xenografts (PDX) and organoids (PDO) provide sign...

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Bibliographic Details
Main Authors: Nicole J. Chew, Terry C. C. Lim Kam Sian, Elizabeth V. Nguyen, Sung-Young Shin, Jessica Yang, Mun N. Hui, Niantao Deng, Catriona A. McLean, Alana L. Welm, Elgene Lim, Peter Gregory, Tim Nottle, Tali Lang, Melissa Vereker, Gary Richardson, Genevieve Kerr, Diana Micati, Thierry Jardé, Helen E. Abud, Rachel S. Lee, Alex Swarbrick, Roger J. Daly
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Breast Cancer Research
Subjects:
Targeted therapy
Oncogene
Fibroblast growth factor receptor
SKI proto-oncogene
Precision oncology
Online Access:https://doi.org/10.1186/s13058-021-01461-4

Internet

https://doi.org/10.1186/s13058-021-01461-4

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