Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

Abstract Background Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of karyopherins to be dysregulated in hepatocarcinogenesis including karyophe...

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Bibliographic Details
Main Authors: Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, Esther Herpel, Benjamin Goeppert, Stephanie Roessler, Alessandro Ori, Peter Schirmacher, Kai Breuhahn, Stephan Singer
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell Communication and Signaling
Subjects:
Karyopherin
Stathmin
HCC
E2F1
TFDP1
Nuclear transport
Online Access:https://doi.org/10.1186/s12964-019-0456-x

Internet

https://doi.org/10.1186/s12964-019-0456-x

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