Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology

Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology

The nuclear hormone receptor (NR) superfamily comprises approximately 50 evolutionarily conserved proteins that play major roles in gene regulation by prototypically acting as ligand-dependent transcription factors. Besides their central role in physiology, NRs have been largely used as therapeutic...

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Bibliographic Details
Main Authors: Lisa M. Sevilla, Paloma Pérez
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
glucocorticoids
glucocorticoid receptor
mineralocorticoid receptor
skin homeostasis
epidermal keratinocytes
transgenic mouse models
differentiation
inflammation
mitogen-activated protein kinase (MAPK) nuclear factor-kappaB (NF-κB) signaling
Online Access:http://www.mdpi.com/1422-0067/19/7/1906

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http://www.mdpi.com/1422-0067/19/7/1906

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