1,4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1

1,4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1

Intervertebral disc degeneration (IVDD) is a major cause of many spinal diseases characterized mainly by nucleus pulposus degradation. 1,4-dihydropyridine (DHP), a new activator of sirtuin-1 (sirt1), has been reported to have anti-oxidative effects. The aim of this study is to investigate the effect...

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Bibliographic Details
Main Authors: Yuxin Song, Zhan Wang, Lin Liu, Suifeng Zhang, Hui Zhang, Yaowen Qian
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
1,4-Dihydropyridine
Nucleus pulposus cells
Oxidative stress
Inflammation
Sirtuin-1
Online Access:http://www.sciencedirect.com/science/article/pii/S075333221935214X

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http://www.sciencedirect.com/science/article/pii/S075333221935214X

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