Tissue-specific and mosaic imprinting defects underlie opposite congenital growth disorders in mice.
Differential DNA methylation defects of H19/IGF2 are associated with congenital growth disorders characterized by opposite clinical pictures. Due to structural differences between human and mouse, the mechanisms by which mutations of the H19/IGF2 Imprinting Control region (IC1) result in these disea...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-02-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5839592?pdf=render |