Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis

Abstract Background Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong survival in HER2-positive breast cancer patients. Benefit stems primarily from improved control of systemic disease, but up to 50% of patients progress to incurable brain metastases due to acquired resista...

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Bibliographic Details
Main Authors: Aadya Nagpal, Richard P. Redvers, Xiawei Ling, Scott Ayton, Miriam Fuentes, Elnaz Tavancheh, Irmina Diala, Alshad Lalani, Sherene Loi, Steven David, Robin L. Anderson, Yvonne Smith, Delphine Merino, Delphine Denoyer, Normand Pouliot
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Breast Cancer Research
Subjects:
TBCP-1
HER2-positive breast cancer
Brain metastasis
Syngeneic mouse model
Neratinib
Ferroptosis
Online Access:http://link.springer.com/article/10.1186/s13058-019-1177-1

Internet

http://link.springer.com/article/10.1186/s13058-019-1177-1

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