Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are...

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Bibliographic Details
Main Authors: Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden, Kevin M McBride, Richard D Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1004654

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https://doi.org/10.1371/journal.pgen.1004654

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