Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge

Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge

Despite robust secondary T cell expansion primed by vaccination, the impact on primary immune responses to heterotypic antigens remains undefined. Here we show that secondary expansion of epitope-specific memory CD8+ T cells primed by prior infection with recombinant pathogens limits the primary exp...

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Bibliographic Details
Main Authors: Lexus R. Johnson, Orr-El Weizman, Moritz Rapp, Sing Sing Way, Joseph C. Sun
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
CD8+ T cell
NK cell
antigen presenting cell
recombinant Listeria monocytogenes
mouse cytomegalovirus
vaccination
clonal expansion
recall response
antigen competition
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312414

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http://www.sciencedirect.com/science/article/pii/S2211124716312414

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