Functional significance of HCM mutants of tropomyosin, V95A and D175N, studied with in vitro motility assays

Functional significance of HCM mutants of tropomyosin, V95A and D175N, studied with in vitro motility assays

The majority of hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere proteins. We examined tropomyosin (Tpm)’s HCM mutants in humans, V95A and D175N, with in vitro motility assay using optical tweezers to evaluate the effects of the Tpm mutations on the actomyosin interaction at the...

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Bibliographic Details
Main Authors: Shuya Ishii, Madoka Suzuki, Shin’ichi Ishiwata, Masataka Kawai
Format: Article
Language:English
Published: The Biophysical Society of Japan 2019-02-01
Series:Biophysics and Physicobiology
Subjects:
hypertrophic cardiomyopathy
tropomyosin mutants
tirf
optical tweezers
sliding velocity and force
Online Access:https://doi.org/10.2142/biophysico.16.0_28

Internet

https://doi.org/10.2142/biophysico.16.0_28

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