Ex vivo cytosolic delivery of functional macromolecules to immune cells.

Ex vivo cytosolic delivery of functional macromolecules to immune cells.

Intracellular delivery of biomolecules, such as proteins and siRNAs, into primary immune cells, especially resting lymphocytes, is a challenge. Here we describe the design and testing of microfluidic intracellular delivery systems that cause temporary membrane disruption by rapid mechanical deformat...

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Bibliographic Details
Main Authors: Armon Sharei, Radiana Trifonova, Siddharth Jhunjhunwala, George C Hartoularos, Alexandra T Eyerman, Abigail Lytton-Jean, Mathieu Angin, Siddhartha Sharma, Roberta Poceviciute, Shirley Mao, Megan Heimann, Sophia Liu, Tanya Talkar, Omar F Khan, Marylyn Addo, Ulrich H von Andrian, Daniel G Anderson, Robert Langer, Judy Lieberman, Klavs F Jensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4395260?pdf=render

Internet

http://europepmc.org/articles/PMC4395260?pdf=render

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