MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.

Bibliographic Details
Main Authors: Can Liu, Ruifang Liu, Dingxiao Zhang, Qu Deng, Bigang Liu, Hsueh-Ping Chao, Kiera Rycaj, Yoko Takata, Kevin Lin, Yue Lu, Yi Zhong, John Krolewski, Jianjun Shen, Dean G. Tang
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14270

Internet

https://doi.org/10.1038/ncomms14270

Similar Items