Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures

Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures

Conventional two-dimensional (2D) cell cultures are grown on rigid plastic substrates with unrealistic concentration gradients of O2, nutrients, and treatment agents. More importantly, 2D cultures lack cell–cell and cell–extracellular matrix (ECM) interactions, which are critical...

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Bibliographic Details
Main Authors: Teresa W.-M. Fan, Salim S. El-Amouri, Jessica K. A. Macedo, Qing Jun Wang, Huan Song, Teresa Cassel, Andrew N. Lane
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Metabolites
Subjects:
selenite
cancer metabolism
A549
PANC1
13C6-glucose tracer
2D cell cultures
3D spheroids
Online Access:http://www.mdpi.com/2218-1989/8/3/40

Internet

http://www.mdpi.com/2218-1989/8/3/40

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