Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration

Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration

Background: Exaggerated beat-to-beat variability of ventricular action potential duration (APD) is linked to arrhythmogenesis. Sympathetic stimulation has been shown to increase QT interval variability, but its effect on ventricular APD in humans has not been determined.Methods and Results: Eleven h...

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Bibliographic Details
Main Authors: Bradley Porter, Martin J. Bishop, Simon Claridge, Jonathan Behar, Benjamin J. Sieniewicz, Jessica Webb, Justin Gould, Mark O'Neill, Christopher A. Rinaldi, Reza Razavi, Jaswinder S. Gill, Peter Taggart
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Physiology
Subjects:
arrhythmia
action potential duration
sympathetic nervous system
activation recovery interval
beta-blocker
heart failure
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00328/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00328/full

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