Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells1[S]

Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells1[S]

The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS), leading to a 4-fold increase in SM mass in tumor cells. In the present study, we investigated the source of the ceramides required to sustain t...

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Bibliographic Details
Main Authors: Maria Laura Martin, Gerhard Liebisch, Stefan Lehneis, Gerd Schmitz, María Alonso-Sande, Joan Bestard-Escalas, Daniel H. Lopez, José Manuel García-Verdugo, Mario Soriano-Navarro, Xavier Busquets, Pablo V. Escribá, Gwendolyn Barceló-Coblijn
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Journal of Lipid Research
Subjects:
antitumor drug
sphingolipid metabolism
mass spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520421820

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http://www.sciencedirect.com/science/article/pii/S0022227520421820

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