N6-isopentenyladenosine and analogs activate the NRF2-mediated antioxidant response

N6-isopentenyladenosine and analogs activate the NRF2-mediated antioxidant response

N6-isopentenyladenosine (i6A), a naturally occurring modified nucleoside, inhibits the proliferation of human tumor cell lines in vitro, but its mechanism of action remains unclear. Treatment of MCF7 human breast adenocarcinoma cells with i6A or with three synthetic analogs (allyl6A, benzyl6A, and...

Full description

Bibliographic Details
Main Authors: Alice Dassano, Mariateresa Mancuso, Paola Giardullo, Loris De Cecco, Pierangela Ciuffreda, Enzo Santaniello, Anna Saran, Tommaso A. Dragani, Francesca Colombo
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Modified nucleosides
Gene expression
Reactive oxygen species
Anti-inflammatory drug
Pathway analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000482

Internet

http://www.sciencedirect.com/science/article/pii/S2213231714000482

Similar Items