DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.

Bibliographic Details
Main Authors: Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng, Junjie Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19941-0

Internet

https://doi.org/10.1038/s41467-020-19941-0

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