DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.

Bibliographic Details
Main Authors:	Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng, Junjie Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19941-0

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spelling	doaj-4244008ca6074117babe9a1796cb68c82021-05-11T08:58:59ZengNature Publishing GroupNature Communications2041-17232020-12-0111111510.1038/s41467-020-19941-0DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunityXiaona Sun0Ting Liu1Jun Zhao2Hansong Xia3Jun Xie4Yu Guo5Li Zhong6Mi Li7Qing Yang8Cheng Peng9Isabelle Rouvet10Alexandre Belot11Hong-Bing Shu12Pinghui Feng13Junjie Zhang14The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan UniversityThe State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan UniversitySection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern CaliforniaSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern CaliforniaThe State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan UniversityThe State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan UniversityFrontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan UniversityDepartment of Burns and Plastic Surgery, 3rd Xiangya Hospital, Central South UniversityHospices Civils de Lyon, Centre de Biotechnologie Cellulaire et BiothèqueCentre International de Recherche en Infectiologie, CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University of LyonFrontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan UniversitySection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern CaliforniaThe State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan UniversityThe enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.https://doi.org/10.1038/s41467-020-19941-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaona Sun Ting Liu Jun Zhao Hansong Xia Jun Xie Yu Guo Li Zhong Mi Li Qing Yang Cheng Peng Isabelle Rouvet Alexandre Belot Hong-Bing Shu Pinghui Feng Junjie Zhang
spellingShingle	Xiaona Sun Ting Liu Jun Zhao Hansong Xia Jun Xie Yu Guo Li Zhong Mi Li Qing Yang Cheng Peng Isabelle Rouvet Alexandre Belot Hong-Bing Shu Pinghui Feng Junjie Zhang DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity Nature Communications
author_facet	Xiaona Sun Ting Liu Jun Zhao Hansong Xia Jun Xie Yu Guo Li Zhong Mi Li Qing Yang Cheng Peng Isabelle Rouvet Alexandre Belot Hong-Bing Shu Pinghui Feng Junjie Zhang
author_sort	Xiaona Sun
title	DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_short	DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_full	DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_fullStr	DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_full_unstemmed	DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_sort	dna-pk deficiency potentiates cgas-mediated antiviral innate immunity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-12-01
description	The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.
url	https://doi.org/10.1038/s41467-020-19941-0
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DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

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