DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.
Main Authors: | Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng, Junjie Zhang |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-19941-0 |
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