Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies

Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies

The Atlas of Diabetes reports 415 million diabetics in the world, a number that has surpassed in half the expected time the twenty year projection. Type 2 diabetes is the most frequent form of the disease; it is characterized by a defect in the secretion of insulin and a resistance in its target org...

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Bibliographic Details
Main Authors: Marie Jazmín Sarabia-Sánchez, Pedro Josué Trejo-Soto, José Miguel Velázquez-López, Carlos Carvente-García, Rafael Castillo, Alicia Hernández-Campos, Claudia Avitia-Domínguez, Daniel Enríquez-Mendiola, Erick Sierra-Campos, Mónica Valdez-Solana, José Manuel Salas-Pacheco, Alfredo Téllez-Valencia
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
protein tyrosine phosphatase 1B
type 2 diabetes
benzimidazole derivatives
enzyme inhibition
docking
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/22/12/2262

Internet

https://www.mdpi.com/1420-3049/22/12/2262

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