Design, Synthesis and Biological Evaluation of 6,7-Disubstituted-4-phenoxyquinoline Derivatives Bearing Pyridazinone Moiety as c-Met Inhibitors

Design, Synthesis and Biological Evaluation of 6,7-Disubstituted-4-phenoxyquinoline Derivatives Bearing Pyridazinone Moiety as c-Met Inhibitors

Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, a series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing pyridazinone derivative...

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Bibliographic Details
Main Authors: Xiaobo Liu, Jianlan Kou, Zhen Xiao, Fajuan Tian, Jiayi Hu, Pengwu Zheng, Wufu Zhu
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
quinoline derivatives
pyridazinone
c-Met
antiproliferative activity
Online Access:http://www.mdpi.com/1420-3049/23/7/1543

Internet

http://www.mdpi.com/1420-3049/23/7/1543

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