Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin

Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin

Objective: Relapsed hepatoblastoma (HBL) and upfront hepatocellular carcinoma (HCC) are notoriously chemoresistant tumors associated with poor outcomes. Gankyrin (Gank) is a known oncogene that is overexpressed in pediatric liver cancer and implicated in chemo-resistance. The goal of this study was...

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Bibliographic Details
Main Authors: Amber M. D’Souza, Ashley Cast, Meenasri Kumbaji, Maria Rivas, Ruhi Gulati, Michael Johnston, David Smithrud, James Geller, Nikolai Timchenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
hepatoblastoma (HBL)
cjoc42
tumor suppressors
oncogene
liver cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.580722/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.580722/full

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