Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2

Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2

Abstract Background Early invasion and metastasis are responsible for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC), and epithelial-to-mesenchymal transition (EMT) is recognized as a crucial biological progress in driving tumor invasion and metastasis. The transcription factor FOXO...

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Bibliographic Details
Main Authors: Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang, Guoping Wang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic ductal adenocarcinoma
Epithelial-to-mesenchymal transition
FOXO3a
SPRY2
β-Catenin/TCF4 pathway
Online Access:http://link.springer.com/article/10.1186/s13046-019-1046-x

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http://link.springer.com/article/10.1186/s13046-019-1046-x

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