Context-specific and immune cell–dependent anti-tumor activities of α1-antitrypsin

α1-antitrypsin (AAT), a circulating glycoprotein that rises during acute phase responses and healthy pregnancies, exhibits immunomodulatory properties in several T-cell–dependent immune pathologies. However, AAT does not interfere with isolated T-cell responses; instead, it facilitates polarization...

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Bibliographic Details
Main Authors: Ofer Guttman, Gabriella Sara Freixo-Lima, Ziv Kaner, Yotam Lior, Peleg Rider, Eli C. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00559/full