Engineered oncolytic virus for the treatment of cholesteatoma: A pilot in vivo study

Engineered oncolytic virus for the treatment of cholesteatoma: A pilot in vivo study

Objective Determine if oncolytic herpes simplex virus (oHSV) can eradicate cholesteatoma (CHST) in a gerbil model. Methods An in vivo model of CHST was developed in Mongolian gerbils by combining Pseudomonas aeruginosa inoculation with double ligation of the external auditory canal (EAC). CHST size...

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Bibliographic Details
Main Authors: Ravi N. Samy, Brian R. Earl, Noga Lipschitz, Ivy Schweinzger, Mark Currier, Timothy Cripe
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Laryngoscope Investigative Otolaryngology
Subjects:
Cholesteatoma
oncolytic virotherapy
oHSV
Online Access:https://doi.org/10.1002/lio2.307

Internet

https://doi.org/10.1002/lio2.307

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