Nucleotide Resolution Comparison of Transcription of Human Cytomegalovirus and Host Genomes Reveals Universal Use of RNA Polymerase II Elongation Control Driven by Dissimilar Core Promoter Elements

Nucleotide Resolution Comparison of Transcription of Human Cytomegalovirus and Host Genomes Reveals Universal Use of RNA Polymerase II Elongation Control Driven by Dissimilar Core Promoter Elements

Human cytomegalovirus infects more than half of humans, persists silently in virtually all tissues, and produces life-threatening disease in immunocompromised individuals. HCMV is also the most common infectious cause of birth defects and the leading nongenetic cause of sensorineural hearing loss in...

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Bibliographic Details
Main Authors: Mrutyunjaya Parida, Kyle A. Nilson, Ming Li, Christopher B. Ball, Harrison A. Fuchs, Christine K. Lawson, Donal S. Luse, Jeffery L. Meier, David H. Price
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
core promoter elements
P-TEFb
PRO-Seq
RNA polymerase II
RNA4.9
cytomegalovirus
Online Access:https://doi.org/10.1128/mBio.02047-18

Internet

https://doi.org/10.1128/mBio.02047-18

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