A Fourth KLK4 Mutation Is Associated with Enamel Hypomineralisation and Structural Abnormalities

A Fourth KLK4 Mutation Is Associated with Enamel Hypomineralisation and Structural Abnormalities

“Amelogenesis imperfecta” (AI) describes a group of genetic conditions that result in defects in tooth enamel formation. Mutations in many genes are known to cause AI, including the gene encoding the serine protease, kallikrein related peptidase 4 (KLK4), expressed during the maturation stage of ame...

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Bibliographic Details
Main Authors: Claire E. L. Smith, Jennifer Kirkham, Peter F. Day, Francesca Soldani, Esther J. McDerra, James A. Poulter, Christopher F. Inglehearn, Alan J. Mighell, Steven J. Brookes
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Physiology
Subjects:
KLK4
enamel
phenotype
mutation
amelogenesis imperfecta
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00333/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00333/full

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