Cyclisation Increases the Stability of the Sea Anemone Peptide APETx2 but Decreases Its Activity at Acid-Sensing Ion Channel 3

Cyclisation Increases the Stability of the Sea Anemone Peptide APETx2 but Decreases Its Activity at Acid-Sensing Ion Channel 3

APETx2 is a peptide isolated from the sea anemone <em>Anthopleura elegantissima</em>.<em> </em>It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic f...

Full description

Bibliographic Details
Main Authors: Lachlan D. Rash, Glenn F. King, Paul F. Alewood, Mehdi Mobli, Andreas Brust, Jonas E. Jensen
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Marine Drugs
Subjects:
sea anemone
<strong> </strong>peptide
<strong> </strong>APETx2
ASIC3
cyclisation
truncation
stability
Online Access:http://www.mdpi.com/1660-3397/10/7/1511

Internet

http://www.mdpi.com/1660-3397/10/7/1511

Similar Items