Cyclisation Increases the Stability of the Sea Anemone Peptide APETx2 but Decreases Its Activity at Acid-Sensing Ion Channel 3
APETx2 is a peptide isolated from the sea anemone <em>Anthopleura elegantissima</em>.<em> </em>It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic f...
Main Authors: | Lachlan D. Rash, Glenn F. King, Paul F. Alewood, Mehdi Mobli, Andreas Brust, Jonas E. Jensen |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2012-07-01
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Series: | Marine Drugs |
Subjects: | |
Online Access: | http://www.mdpi.com/1660-3397/10/7/1511 |
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