Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression

Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression

Bulleyaconitine A (BAA), a C19-diterpenoid alkaloid, has been prescribed as a nonnarcotic analgesic to treat chronic pain over four decades in China. The present study investigated its inhibition in morphine-induced withdrawal symptoms, conditioned place preference (CPP) and locomotor sensitization,...

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Bibliographic Details
Main Authors: Meng-Jing Zhao, Mi-Ya Wang, Le Ma, Khalil Ali Ahmad, Yong-Xiang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
bulleyaconitine A
dynorphin A
microglia
nucleus accumbens
hippocampus
physical dependence
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.620926/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.620926/full

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