Handling Permutation in Sequence Comparison: Genome-Wide Enhancer Prediction in Vertebrates by a Novel Non-Linear Alignment Scoring Principle.

Handling Permutation in Sequence Comparison: Genome-Wide Enhancer Prediction in Vertebrates by a Novel Non-Linear Alignment Scoring Principle.

Enhancers have been described to evolve by permutation without changing function. This has posed the problem of how to predict enhancer elements that are hidden from alignment-based approaches due to the loss of co-linearity. Alignment-free algorithms have been proposed as one possible solution. How...

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Bibliographic Details
Main Authors: Dirk Dolle, Juan L Mateo, Michael P Eichenlaub, Rebecca Sinn, Robert Reinhardt, Burkhard Höckendorf, Daigo Inoue, Lazaro Centanin, Laurence Ettwiller, Joachim Wittbrodt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4624239?pdf=render

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http://europepmc.org/articles/PMC4624239?pdf=render

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