Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons

Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder in the old population. Among its monogenic variants, a frequent cause is a mutation in the Parkin gene (Prkn). Deficient function of Parkin triggers ubiquitous mitochondrial dysfunction and inflammation in the brain...

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Bibliographic Details
Main Authors: J. Key, A.K. Mueller, S. Gispert, L. Matschke, I. Wittig, O. Corti, C. Münch, N. Decher, G. Auburger
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Mitochondria
Parkin
Ubiquitin
Calcium
Firing frequency
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300385

Internet

http://www.sciencedirect.com/science/article/pii/S0969996119300385

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