Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with <i>Clostridium perfringens</i> Enterotoxin (CPE)

Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with <i>Clostridium perfringens</i> Enterotoxin (CPE)

Pancreatic cancer (PC) is one of the most lethal cancers worldwide, associated with poor prognosis and restricted therapeutic options. <i>Clostridium perfringens</i> enterotoxin (CPE), is a pore-forming (oncoleaking) toxin, which binds to claudin-3 and -4 (Cldn3/4) causing selective cyto...

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Bibliographic Details
Main Authors: Jessica Pahle, Dennis Kobelt, Jutta Aumann, Diana Behrens, Ole Daberkow, Margarita Mokritzkij, Jörg Piontek, Ulrike Stein, Wolfgang Walther
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
<i>Clostridium perfringens</i> enterotoxin (CPE)
pancreatic cancer
gene therapy
suicide gene
combination therapy
Online Access:https://www.mdpi.com/2072-6694/13/17/4393

Internet

https://www.mdpi.com/2072-6694/13/17/4393

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