Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation.

Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation.

New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox sibling of NO• attracting considerable attention for the treatment of cardiovascular disorders, eliciting cGMP-dependent vasodilatation yet cGMP-independent po...

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Bibliographic Details
Main Authors: Eliane Q Lin, Jennifer C Irvine, Anh H Cao, Amy E Alexander, Jane E Love, Ruchi Patel, Julie R McMullen, David M Kaye, Barbara K Kemp-Harper, Rebecca H Ritchie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3323591?pdf=render

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http://europepmc.org/articles/PMC3323591?pdf=render

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