Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach

Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach

Abstract Background In this study, we demonstrate that our modified Gene Set Enrichment Analysis (GSEA) method, drug perturbation GSEA (dpGSEA), can detect phenotypically relevant drug targets through a unique transcriptomic enrichment that emphasizes biological directionality of drug-derived gene s...

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Bibliographic Details
Main Authors: Mike Fang, Brian Richardson, Cheryl M. Cameron, Jean-Eudes Dazard, Mark J. Cameron
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Bioinformatics
Subjects:
Transcriptomics
Gene set enrichment analysis
Drug discovery
Online Access:https://doi.org/10.1186/s12859-020-03929-0

Internet

https://doi.org/10.1186/s12859-020-03929-0

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