Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector func...

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Main Authors:	Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04719-2

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spelling	doaj-428103db6a8c40348a0ae092d9d2a9822021-05-11T09:57:19ZengNature Publishing GroupNature Communications2041-17232018-06-019111510.1038/s41467-018-04719-2Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in miceRóisín M. Loftus0Nadine Assmann1Nidhi Kedia-Mehta2Katie L. O’Brien3Arianne Garcia4Conor Gillespie5Jens L. Hukelmann6Peter J. Oefner7Angus I. Lamond8Clair M. Gardiner9Katja Dettmer10Doreen A. Cantrell11Linda V. Sinclair12David K. Finlay13School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinCentre for Gene Regulation and Expression, School of Life Sciences, University of DundeeInstitute of Functional Genomics, University of RegensburgCentre for Gene Regulation and Expression, School of Life Sciences, University of DundeeSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinInstitute of Functional Genomics, University of RegensburgDivision of Cell Signalling and Immunology, School of Life Sciences, University of DundeeDivision of Cell Signalling and Immunology, School of Life Sciences, University of DundeeSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinGlutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.https://doi.org/10.1038/s41467-018-04719-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Róisín M. Loftus Nadine Assmann Nidhi Kedia-Mehta Katie L. O’Brien Arianne Garcia Conor Gillespie Jens L. Hukelmann Peter J. Oefner Angus I. Lamond Clair M. Gardiner Katja Dettmer Doreen A. Cantrell Linda V. Sinclair David K. Finlay
spellingShingle	Róisín M. Loftus Nadine Assmann Nidhi Kedia-Mehta Katie L. O’Brien Arianne Garcia Conor Gillespie Jens L. Hukelmann Peter J. Oefner Angus I. Lamond Clair M. Gardiner Katja Dettmer Doreen A. Cantrell Linda V. Sinclair David K. Finlay Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice Nature Communications
author_facet	Róisín M. Loftus Nadine Assmann Nidhi Kedia-Mehta Katie L. O’Brien Arianne Garcia Conor Gillespie Jens L. Hukelmann Peter J. Oefner Angus I. Lamond Clair M. Gardiner Katja Dettmer Doreen A. Cantrell Linda V. Sinclair David K. Finlay
author_sort	Róisín M. Loftus
title	Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_short	Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_full	Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_fullStr	Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_full_unstemmed	Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
title_sort	amino acid-dependent cmyc expression is essential for nk cell metabolic and functional responses in mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-06-01
description	Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.
url	https://doi.org/10.1038/s41467-018-04719-2
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Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

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