KR-31761, a Novel K+ATP-Channel Opener, Exerts Cardioprotective Effects by Opening Both Mitochondrial K+ATP and Sarcolemmal K+ATP Channels in Rat Models of Ischemia/Reperfusion-Induced Heart Injury

KR-31761, a Novel K+ATP-Channel Opener, Exerts Cardioprotective Effects by Opening Both Mitochondrial K+ATP and Sarcolemmal K+ATP Channels in Rat Models of Ischemia/Reperfusion-Induced Heart Injury

The cardioprotective effects of KR-31761, a newly synthesized K+ATP opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. In isolated rat hearts subjected to 30-min global ischemia/30-min reperfusion, KR-31761 perfused prior to ischemia significantly increased both the lef...

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Main Authors: Min-Kyu Yang, Sung-Hun Lee, Ho-Won Seo, Kyu-Yang Yi, Sung-Eun Yoo, Byung-Ho Lee, Hun-Jong Chung, Hyung-Sik Won, Chang-Soo Lee, Suk-Hyung Kwon, Wahn-Soo Choi, Hwa-Sup Shin
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319312770

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http://www.sciencedirect.com/science/article/pii/S1347861319312770

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