Differential Motor Neuron Impairment and Axonal Regeneration in Sporadic and Familiar Amyotrophic Lateral Sclerosis with SOD-1 Mutations: Lessons from Neurophysiology

Differential Motor Neuron Impairment and Axonal Regeneration in Sporadic and Familiar Amyotrophic Lateral Sclerosis with SOD-1 Mutations: Lessons from Neurophysiology

Amyotrophic Lateral Sclerosis (ALS) is a degenerative disorder of the motor system. About 10% of cases are familial and 20% of these families have point mutations in the Cu/Zn superoxide dismutase 1 (SOD-1) gene. SOD-1 catalyses the superoxide radical (O−2) into hydrogen peroxide and molecular oxyge...

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Bibliographic Details
Main Authors: Tommaso Bocci, Chiara Pecori, Elisa Giorli, Lucia Briscese, Ferdinando Sartucci, Matteo Caleo, Silvia Tognazzi
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:International Journal of Molecular Sciences
Subjects:
Amyotrophic Lateral Sclerosis
SOD-1 carriers
macro-EMG
MUNE
Online Access:http://www.mdpi.com/1422-0067/12/12/9203/

Internet

http://www.mdpi.com/1422-0067/12/12/9203/

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