Restoration of Cyclo-Gly-Pro-induced salivary hyposecretion and submandibular composition by naloxone in mice.

Restoration of Cyclo-Gly-Pro-induced salivary hyposecretion and submandibular composition by naloxone in mice.

Cyclo-Gly-Pro (CGP) attenuates nociception, however its effects on salivary glands remain unclear. In this study, we investigated the acute effects of CGP on salivary flow and composition, and on the submandibular gland composition, compared with morphine. Besides, we characterized the effects of na...

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Main Authors: Igor Santana Melo, Návylla Candeia-Medeiros, Jamylle Nunes Souza Ferro, Polliane Maria Cavalcante-Araújo, Tales Lyra Oliveira, Cassio Eráclito Alves Santos, Leia Cardoso-Sousa, Emilia Maria Gomes Aguiar, Stephanie Wutke Oliveira, Olagide Wagner Castro, Renata Pereira Alves-Balvedi, Luciano Pereira Rodrigues, Jandir M Hickmann, Douglas Alexsander Alves, Igor Andrade Santos, Ana Carolina Gomes Jardim, Walter Luiz Siqueira, Angelo Ricardo Fávaro Pipi, Luiz Ricardo Goulart, Emiliano de Oliveira Barreto, Robinson Sabino-Silva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229761

Internet

https://doi.org/10.1371/journal.pone.0229761

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