MiR-181b-5p modulates chemosensitivity of glioma cells to temozolomide by targeting Bcl-2

Chemotherapy is the main postsurgical and adjuvant therapy for glioma, and intrinsic or acquired temozolomide (TMZ) resistance may result in poor prognosis. The miR-181 family was discovered to play an important role in regulating biological functions in glioma, and miR-181b is less expressed in hum...

Full description

Bibliographic Details
Main Authors: Xiyue Zhang, Jiawen Yu, Chunhui Zhao, Huifang Ren, Zhen Yuan, Baihui Zhang, Jingling Zhuang, Jia Wang, Bin Feng
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S075333221835916X