HPV Infection Leaves a DNA Methylation Signature in Oropharyngeal Cancer Affecting Both Coding Genes and Transposable Elements

HPV Infection Leaves a DNA Methylation Signature in Oropharyngeal Cancer Affecting Both Coding Genes and Transposable Elements

HPV oncoproteins can modulate DNMT1 expression and activity, and previous studies have reported both gene-specific and global DNA methylation alterations according to HPV status in head and neck cancer. However, validation of these findings and a more detailed analysis of the transposable elements (...

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Bibliographic Details
Main Authors: Diego Camuzi, Luisa Aguirre Buexm, Simone de Queiroz Chaves Lourenço, Davide Degli Esposti, Cyrille Cuenin, Monique de Souza Almeida Lopes, Francesca Manara, Fazlur Rahman Talukdar, Zdenko Herceg, Luis Felipe Ribeiro Pinto, Sheila Coelho Soares-Lima
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
oropharyngeal squamous cell carcinoma
HPV
DNA methylation
transposable elements
gene expression
overall survival
Online Access:https://www.mdpi.com/2072-6694/13/14/3621

Internet

https://www.mdpi.com/2072-6694/13/14/3621

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