Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

Ataxin-2 (Atx2) is a translational control molecule mutated in spinocerebellar ataxia type II and amyotrophic lateral sclerosis. While intrinsically disordered domains (IDRs) of Atx2 facilitate mRNP condensation into granules, how IDRs work with structured domains to enable positive and negative reg...

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Bibliographic Details
Main Authors: Amanjot Singh, Joern Hulsmeier, Arvind Reddy Kandi, Sai Shruti Pothapragada, Jens Hillebrand, Arnas Petrauskas, Khushboo Agrawal, Krishnan RT, Devasena Thiagarajan, Deepa Jayaprakashappa, K VijayRaghavan, Mani Ramaswami, Baskar Bakthavachalu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
Ataxin-2
TRIBE
mRNA
translational control
rnp granule
neurodegeneration
Online Access:https://elifesciences.org/articles/60326

Internet

https://elifesciences.org/articles/60326

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