Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation
Ataxin-2 (Atx2) is a translational control molecule mutated in spinocerebellar ataxia type II and amyotrophic lateral sclerosis. While intrinsically disordered domains (IDRs) of Atx2 facilitate mRNP condensation into granules, how IDRs work with structured domains to enable positive and negative reg...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-03-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/60326 |