Over-Expression of CYP2E1 mRNA and Protein: Implications of Xenobiotic Induced Damage in Patients with <em>De Novo</em> Acute Myeloid Leukemia with inv(16)(p13.1q22); <em>CBF</em><em>β</em><em>-MYH11</em>

Over-Expression of CYP2E1 mRNA and Protein: Implications of Xenobiotic Induced Damage in Patients with <em>De Novo</em> Acute Myeloid Leukemia with inv(16)(p13.1q22); <em>CBF</em><em>β</em><em>-MYH11</em>

Environmental exposure to benzene occurs through cigarette smoke, unleaded gasoline and certain types of plastic. Benzene is converted to hematotoxic metabolites by the hepatic phase-I enzyme CYP2E1, and these metabolites are detoxified by the phase-II enzyme NQO1. The genes encoding these enzymes a...

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Bibliographic Details
Main Authors: Carlos E. Bueso-Ramos, Michael H. Fernandez, Martin H. Nguyen, Saroj Vadhan-Raj, Rashmi Kanagal-Shamanna, Weiqiang Zhao, L. Jeffrey Medeiros
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Environmental Research and Public Health
Subjects:
CYP2E1
NQO1
AML with inv(16)
<em>de novo </em>AML
CBFB-MYH11
benzene
xenobiotic induced damage
Online Access:http://www.mdpi.com/1660-4601/9/8/2788

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http://www.mdpi.com/1660-4601/9/8/2788

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