Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein

Accumulation of α-Synuclein (αSyn) in nigral dopaminergic neurons is commonly seen in patients with Parkinson′s disease (PD). We recently reported that transduction of intracellular single-chain intrabody targeting the 53–87 amino acid residues of human αSyn by recombinant adeno associated viral vec...

Full description

Bibliographic Details
Main Authors: Yun-Hsiang Chen, Kuo-Jen Wu, Wei Hsieh, Brandon K. Harvey, Barry J. Hoffer, Yun Wang, Seong-Jin Yu
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
AAV
Online Access:https://www.mdpi.com/2073-4425/12/6/948