Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

Iron accumulation and tau protein deposition are pathological features of Alzheimer's (AD) and Parkinson's diseases (PD). Soluble tau protein is lower in affected regions of these diseases, and we previously reported that tau knockout mice display motor and cognitive behavioral abnormities...

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Bibliographic Details
Main Authors: Peng Lei, Scott Ayton, Ambili Thoppuvalappil Appukuttan, Irene Volitakis, Paul A. Adlard, David I. Finkelstein, Ashley I. Bush
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Neurobiology of Disease
Subjects:
Tau
Parkinson's disease
Alzheimer's disease
Clioquinol
Iron
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611500087X

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http://www.sciencedirect.com/science/article/pii/S096999611500087X

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