The Functional Role of CONNEXIN 26 Mutation in Nonsyndromic Hearing Loss, Demonstrated by Zebrafish Connexin 30.3 Homologue Model

The Functional Role of CONNEXIN 26 Mutation in Nonsyndromic Hearing Loss, Demonstrated by Zebrafish Connexin 30.3 Homologue Model

Nonsyndromic hearing loss (NSHL) is of great clinical importance, and mutations in the <i>GJB2</i> gene and the encoded human CONNEXIN 26 (CX26) protein play important roles in the genetic pathogenesis. The CX26 p.R184Q mutation was shown to be a dominant-negative effect in our previous...

Full description

Bibliographic Details
Main Authors: Hsuan-An Su, Ting-Wei Lai, Shuan-Yow Li, Tzu-Rong Su, Jiann-Jou Yang, Ching-Chyuan Su
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
non-syndromic hearing loss
zebrafish
GJB2
CONNEXIN 26
Connexin 30.3
behavioral assay
Online Access:https://www.mdpi.com/2073-4409/9/5/1291

Internet

https://www.mdpi.com/2073-4409/9/5/1291

Similar Items