NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation

NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation

NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism to neuroinflammation by dietary intervention.

Bibliographic Details
Main Authors: Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, Zheng-Jiang Zhu, Junying Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25157-7

Internet

https://doi.org/10.1038/s41467-021-25157-7

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